The Second Interval covers the Turns 308-508 AL. It was a time of continued growth for the Holds and Crafts. Near the end, there were droughts in the Igen region. A plague in the last decade of the Interval affected nearly the entirity of the Northern Continent, concentrated in the Benden region.

Igen Weyr was abandoned 20-some Turns before the end of the Interval. In the last Turn of the Interval and the first Turn of the following Pass, a plague spread among the Dragons and Fire-lizards, threatening to wipe out both species.

The novel Dragonsblood takes place, in part, in the Second Interval.

Second Pass Historical Eras of Pern Third Pass