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Substance D is the fictional drug at the center of the drama in Philip K. Dick's novel A Scanner Darkly. An amalgam of the recreational drugs popular when Dick was writing, it provides a vehicle for criticizing irresponsible drug use and drug prohibition.

The different symptoms of long term use of Substance D are presented in the descriptions of the different charcaters:

Bob Arctor (Special Agent Fred): split personality and cross-chatter
Jim Barris = homicidal mania
Ernie Luckman = loss of independent will
Charles Freck = formication (delusional parasitosis or Ekbom's syndrome)

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